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pentobarbital will lower the extent or impact of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.pentobarbital will minimize the extent or impact of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with robust CYP3A4 inducers isn't re